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First Defense Calf Boluses

First Defense Calf Boluses

Regular price $48.55 USD
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Used as an aid in the prevention of neonatal beef and dairy calf scours caused by K99+ E. coli and Coronavirus.

Studies have shown that calves that scour are more susceptible to other diseases later in life and under-perform calves that do not contract scours. The direct, two-part mode-of-action of First Defense delivers specific immunoglobulins at the gut level to immediately protect against disease, while also providing additional antibodies that are absorbed into the bloodstream. These circulating antibodies function like a natural timed-release mechanism, as they are re-secreted into the gut later to provide extended protection. A single dose of First Defense provides a guaranteed level of protection proven to reduce mortality and morbidity from two major causes of calf scours.

Directions: Administer 1 bolus within the first 12 hours after birth. No slaughter withdrawal. OMRI listed and approved for organic operations, check with your certification agency. No refrigeration or mixing required. For best administration results, use Medium Balling Gun (sold separately).


Manufacturer and/or Label Information

Telephone: 800-466-8235
Order Desk: 800-466-8235
Fax: 207-878-2117
THIS SERVICE AND DATA ARE PROVIDED "AS IS". DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. See the Terms of Use for further details.




For veterinary use only

OMRI LISTED For Organic Use


FIRST DEFENSE® is a capsule containing antibodies which aid in the reduction of morbidity and mortality from neonatal calf scours caused by K99+ E. coli and bovine coronavirus. Maximal protection is achieved when administered in the first 12 hours after birth and used in conjunction with good colostrum feeding and calf nutrition programs. Neutralizing antibodies against bovine coronavirus as well as antibodies specific for E. coli K99+ pilus antigens present in FIRST DEFENSE® are prepared from hyperimmune bovine colostrum. A FIRST DEFENSE® capsule containing dried colostral antibodies dissolves readily upon reaching the calf’s stomach to provide passive protection against intestinal infection. Specific antibodies in FIRST DEFENSE® serve to block enterotoxigenic E. coli adherence and interfere with virus infection of intestinal epithelial cells, thereby reducing scours-related morbidity and mortality.


While diarrhea in newborn calves can result from a variety of nutritional and management-related factors, the most common form of scours in calves during the first weeks of life is colibacillosis caused by enterotoxigenic K99+ E. coli (ETEC). ETEC infections alone cause 30-50% of scour-related deaths in newborn calves(1,2). Adherence of ETEC to intestinal epithelial cells via K99 pili permits colonization and enhances enterotoxin induced hypersecretion of electrolytes and water. The resulting profuse yellowish diarrhea can lead to severe dehydration and death(3,4).

An additional 15-38% of neonatal scours mortality is associated with infections caused by coronavirus either alone, or in combination with K99+ E. coli, rotavirus or Cryptosporidium(2). While coronavirus diarrhea is most common between 7-14 days of age, coronavirus has been isolated in high frequency in calves during the neonatal period and is endemic in many dairy herds(2,5).


FIRST DEFENSE® is used as an aid in the reduction of morbidity and mortality from scours caused by K99+ E. coli and bovine coronavirus.


FIRST DEFENSE® has been tested in a total of 473 beef and dairy calves under both laboratory and field conditions. No allergic or other adverse reactions were observed.

Clinical studies showed that 90% (18 of 20) of calves treated with FIRST DEFENSE® in the first 12 hours after birth survived without additional treatment following a severe challenge of K99+ E. coli. In contrast, only 40% (4 of 10) of control calves survived the study interval (five days) under the same challenge conditions. Morbidity, as measured by fecal scores and dehydration scores, was also significantly reduced in FIRST DEFENSE®-treated calves when compared to control calves in this K99+ E. coli challenge trial.

In a similar challenge study with virulent, calf-passaged coronavirus, animals receiving FIRST DEFENSE® had a significant reduction in mortality (0/18 deaths) when compared to untreated controls (4/10 deaths). FIRST DEFENSE®-treated also showed a significant reduction in scouring and dehydration compared to control animals in this study.


FIRST DEFENSE® capsules are supplied in individual, moisture resistant blister packs which can be stored at, or below room temperature -23°C (72°F). Product is not harmed by freezing. If frozen, allow blister package capsule to warm to room temperature before removal from blister and administration. Capsules should remain in their blister packs until administered. Anaphylactic reactions may occur. If an anaphylactic reaction occurs after feeding FIRST DEFENSE®, administer epinephrine, or equivalent. Improper administration of the capsule may cause choking. See the Directions for more information.


A capsule dose of FIRST DEFENSE® should be given to each calf within the first 12 hours after birth. If the calf is to be tube fed, it is recommended to do so prior to dosing. To administer, remove a FIRST DEFENSE® capsule from its blister pack by tearing off the foil backing and follow the instructions recommended below:

1. Place the large end of the capsule in a dosing gun (16 mm/5/8” opening) until firmly seated. Avoid guns with undersized openings which may fracture the capsule shell or oversized openings which could allow the capsule to slip.

2. Restrain the calf. Gently pry open its mouth and place the dosing gun containing the capsule into the back of the throat. Administer the capsule as close to the esophageal opening as possible. Use caution to avoid delivery to the trachea.

3. To assist passage of the capsule down the esophagus and to stimulate a swallowing reflex, stroke the surface of the tongue or the outside of the throat. Whenever possible, bottle feed or allow the calf to suckle immediately after administering the capsule. Watch for signs of breathing difficulty after administering the capsule.

A capsule may block the airway if not properly administered, or if not swallowed by the calf. If the calf shows signs of choking or suffocating, immediately manipulate its body to dislodge the capsule.

4. Dosing gun should be cleaned and dried immediately following administration of capsule to each calf.


1. Haggard, D.L. Bovine enteric colibacillosis. Vet. Clin. N. Amer. Food Animal Prac. 1:495-508, 1985.

2. House, J.A. Economic impact of rotavirus and other neonatal disease agents of animals. JAVMA 173(5):573-576, 1978.

3. Moon, H.W., Whip, S.C. and Skartvedt, S.M. Etologic diagnosis of diarrhea disease of calves: Frequency and methods for detecting interotoxin and K99 antigen production by Escherichia coli. Am. J. Vet. Res. 37:1025-1029, 1976.

4. Moon, H.W. Mechanisms in the pathogenesis of diarrhea: a review. JAVMA 172:443-448, 1978.

5. Crouch, C.F. et al. Prevalence of rotavirus and coronavirus antigens in the feces of normal cows. Canad. J. Comp. Med. 48:340-342, 1984.

Manufactured by: IMMUCELL CORPORATION, 56 Evergreen Drive, Portland, ME 04103


Made in USA

U.S. Veterinary License No. 327

PCN 36B5.00

Rev: 10 (1/2015)

5 single dose capsules

1508 REV: 6

30 single dose capsules

1509 REV: 6

CPN: 1120001.8

COLORADO SERUM COMPANY4950 YORK STREET, P.O. BOX 16428, DENVER, CO, 80216-0428Telephone: 303-295-7527Order Desk: 800-525-2065Fax: 303-295-1923Website: www.colorado-serum.comEmail: colorado-serum@colorado-serum.comTHIS SERVICE AND DATA ARE PROVIDED "AS IS". DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. See the Terms of Use for further details.


Colorado Serum


GENERAL INFORMATION: This product has been shown to be effective for the vaccination of healthy horses, cattle, sheep, goats, and swine against tetanus. This product was licensed prior to the requirement to establish a minimum age for use. The duration of immunity is unknown. For more information regarding efficacy and safety data, see

Safety in pregnant animals is unknown.

Tetanus Toxoid is prepared by detoxifying tetanus toxin in such a manner as to allow the antigenic properties to remain intact. Product is purified, concentrated and adjuvanted to provide a low dose effective immunizing agent.

Each serial is tested for purity, safety, and potency in accordance with USDA requirements.

Tetanus is caused by a neurotoxin produced by growth of Clostridium tetani, an anaerobic (lives without air) micro-organism, in necrotic tissue. Affected animals become stiff, have difficulty swallowing, and have an increased pulse rate. Breathing is labored. Spasmodic contractions of the muscular system occur, such as contracting muscles of the jaw.

Spasmodic contractions of the muscular system occur, such as contracting muscles of the jaw. Thus, the term “lockjaw” is often used. Legs and tail are often stiff with abdominal muscles contracted. Tetanus stricken animals may be unusually sensitive to light and heat. Temperature of the animal generally remains normal, elevating only shortly before death.

Protective antibody levels usually occur about two weeks after the second injection of the primary immunization series. In contrast, administration of Tetanus Antitoxin is recommended for immediate, emergency, passive treatment of exposed animals with unknown vaccination history or with signs of tetanus infection.

DIRECTIONS: Do not vaccinate within 21 days before slaughter. Store at 2-8° C. Do not freeze. Do not mix with other products. Shake well before use. Use entire contents when first opened.

PRECAUTIONS: A transitory local reaction may occur at injection site. Anaphylactoid reaction may occur following administration of products of this nature. If noted, administer adrenalin or equivalent. In case of human exposure, consult a physician.

DOSAGE & ADMINISTRATION: For primary immunization, two doses should be administered subcutaneously or intramuscularly approximately 30 days apart. Use intramuscularly for horses as local reactions are more likely to occur if injected subcutaneously.

Horses: 1 ml IM

Cattle: 1 ml SC or IM

Sheep, Goats, Swine: 0.5 ml SC or IM

Historically, annual single dose revaccination has been recommended. Contact veterinarian for advice.

OTHER INFORMATION: Contains thimerosal and formalin as preservatives. Tetanus Toxoid Concentrate is available in single dose size packaged 10 vials to the carton, and in 10 dose vials.


VLN: 188 / PCN: 8601.00

COLORADO SERUM COMPANY, 4950 York Street, Denver, Colorado 80216


Contact us for information on other Colorado Serum Company products. Fine Veterinary Products since 1923.




Order #

10 - 1 ml vials

10 - 1 dose vials


10 ml

10 doses


CPN: 1101033.3



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