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Zoetis

Eazi-Breed CIDR for Cattle

Eazi-Breed CIDR for Cattle

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***This product cannot be shipped to California.***

Eazi-Breed CIDR (Progesterone) Cattle breeding is more successful with the Eazi-Breed CIDR Cattle Insert (progesterone). It improves the timing and efficiency of beef cow and heifer breeding programs when using Lutalyse. The Eazi-Breed CIDR Insert provides precise control of the estrous cycle, allowing more cattle to be bred in less time. The Eazi-Breed CIDR Insert is indicated for controlling the estrous cycle and ovulation in beef heifers and cows for: artificial insemination, easier estrous detection, planned natural mating, embryo collection and transfer programs, and treating anestrus. Eazi-Breed CIDR Cattle Inserts are administered intravaginally, one per animal, in beef cows and heifers.

The Eazi-Breed CIDR Insert releases progesterone during the seven-day treatment period. To assure satisfactory synchronization, an injection of Lutalyse must be given to all cattle one day before insert removal. Removal of the insert on treatment day seven results in a drop in plasma progesterone, triggering estrus within three days. (Lutalyse is a prescription drug. Do not administer Lutalyse in pregnant animals unless cessation of pregnancy is desired. Improve the effectiveness of reproduction programs by tightening estrus synchronization so groups of cows and heifers come into heat and can be bred in a narrow window. Groups of cows also can be synchronized to return to estrus after insemination for potential rebreeding in a desired time frame. LUTALYSE Sterile Solution (dinoprost tromethamine) is the only prostaglandin product on the market approved for concurrent use with Eazi-Breed CIDR in synchronization protocols of lactating beef cows.

Pack of 10. 

Manufacturer and/or Label Information

ZOETIS INC.
333 PORTAGE STREET, KALAMAZOO, MI, 49007
Telephone: 269-359-4414
Customer Service: 888-963-8471
Website: www.zoetis.com
THIS SERVICE AND DATA ARE PROVIDED "AS IS". DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. See the Terms of Use for further details.
EAZI-BREED™ CIDR®

Zoetis

(progesterone intravaginal insert)

Cattle Insert

Each EAZI-BREED CIDR Cattle Insert contains 1.38 grams of progesterone in molded silicone over a flexible nylon spine. Attached to each EAZI-BREED CIDR Cattle Insert is a polyester tail.

NET CONTENTS

10 EAZI-BREED CIDR Cattle Inserts per bag

Approved by FDA under NADA # 141-200

DRUG FACTS

Active Ingredient: Progesterone, 1.38 grams per EAZI-BREED CIDR Cattle Insert

Uses:

• Synchronization of estrus in lactating dairy cows, suckled beef cows, and replacement beef and dairy heifers

• Induction of estrous cycles in anestrous lactating dairy cows

• Synchronization of the return to estrus in lactating dairy cows inseminated at the immediately preceding estrus

• Advancement of first postpartum estrus in suckled beef cows

• Advancement of first pubertal estrus in replacement beef heifers

Removal of the EAZI-BREED CIDR Cattle Insert on treatment Day 7 results in a rapid fall in plasma progesterone levels, which results in the occurrence of estrus in those animals responding to treatment.

WARNINGS:


Withdrawal Periods: Neither a pre-slaughter withdrawal interval nor a milk discard time is required when this product is used according to label directions.


User Safety Warning: Avoid contact with skin by wearing protective gloves when handling the inserts. Not for use in humans. Keep out of reach of children.

Environmental Warning: Store used (removed) EAZI-BREED CIDR Cattle Inserts in a plastic bag or other sealable container until they can be properly disposed in accordance with applicable local, state and Federal regulations.

DO NOT USE:

• An insert more than once. To prevent the potential transmission of venereal and blood born disease the EAZI-BREED CIDR Cattle Insert should be disposed after a single use.

• In beef or dairy heifers of insufficient size or age for breeding or in cattle with abnormal, immature or infected genital tracts.

• In beef cows that are less than 20 days postpartum for synchronization of estrus or advancement of first postpartum estrus because safety and effectiveness have not been evaluated.

• In lactating dairy cows less than 40 days postpartum for synchronization of estrus or synchronization of the return to estrus because safety and effectiveness have not been evaluated.

• In anestrous lactating dairy cows less than 42 days or greater than 78 days postpartum for induction of estrous cycles because safety and effectiveness have not been evaluated.

YOU MAY NOTICE:

• Increased loss of EAZI-BREED CIDR Cattle Inserts in animals housed under crowded conditions, especially in heifers. Avoid crowded conditions during treatment as other cattle, particularly heifers, may remove EAZI-BREED CIDR Cattle Inserts by pulling on the tail of the EAZI-BREED CIDR Cattle Insert. If loss rates are high re-evaluate insertion technique and cattle handling facilities.

• Clear, cloudy, yellow or bloody mucus on the outside of EAZI-BREED CIDR Cattle Insert when removed from animals. The mucus may have an offensive odor. This is a result of irritation to the vaginal lining by the presence of the EAZI-BREED CIDR Cattle Insert, and generally clears between the time of removal and insemination. Such irritation does not affect fertility at inseminations following treatment.

• Use of EAZI-BREED Cattle Insert for periods of longer than 7 days may result in reduced fertility.

• Reduced conception rates to inseminations conducted immediately following removal of the EAZI-BREED CIDR Cattle Insert when used for induction of estrous cycles in anestrous lactating dairy cows. Such reductions in conception rate are not expected to result in reduced pregnancy rates.

• Reduced pregnancy rates to inseminations conducted immediately prior to administration of EAZI-BREED CIDR Cattle Inserts used for synchronizing the return to estrus in lactating dairy cows.

DIRECTIONS:

Lactating Dairy Cows

For Synchronization of Estrus in Lactating Dairy Cows:

• Administer one EAZI-BREED CIDR Cattle Insert per animal and remove 7 days later (for example if administered on a Monday remove the following Monday).

• Administer 5 mL LUTALYSE® Sterile Solution at the time of removal of the EAZI-BREED CIDR Cattle Insert.

• Observe animals for signs of estrus on Days 2 to 5 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals found in estrus following typical herd practices.

For Induction of Estrous Cycles in Anestrous Lactating Dairy Cows:

• For induction of estrous cycles in anestrous lactating dairy cows, anestrous dairy cows can be identified using any of the following methods:

- Cows not observed in estrus since calving.

- Cows diagnosed twice without a corpus luteum on either ovary via ultrasonography at a 7 to 14 day interval, such as on Day 35 and Day 42 post calving.

- Cows with low concentration of progesterone in two blood or milk samples collected at a 7 to 14 day interval, such as samples collected on Day 35 and 42 post calving.

• Administer one EAZI-BREED CIDR Cattle Insert per anestrous cow and remove 7 days later (for example if administered on a Monday remove the following Monday).

• If insemination is intended, observe cows on Days 2 to 5 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals found in estrus following typical herd practices.

For Synchronization of the Return to Estrus in Lactating Dairy Cows Inseminated at the Immediately Preceding Estrus:

• Administer one EAZI-BREED CIDR Cattle Insert per animal 14±1 days after insemination. Remove EAZI-BREED CIDR Cattle Insert 7 days later (for example, if administered on a Monday remove on the following Monday).

• Observe animals for signs of estrus on Days 1 to 3 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals about 12 hours after onset of estrus.

• Note: Do not administer LUTALYSE® Sterile Solution or other prostaglandin products to cows for synchronization of the return to estrus, as this will interrupt pregnancy that may have occurred at the immediately previous insemination.

Suckled Beef Cows, Replacement Beef and Dairy Heifers: For synchronization of estrus in suckled beef cows and replacement beef and dairy heifers, advancement of first postpartum estrus in suckled beef cows, and advancement of first pubertal estrus in beef heifers:

• Administer one EAZI-BREED CIDR Cattle Insert per animal for 7 days (for example, if administered on a Monday remove on the following Monday).

• Inject 5 mL LUTALYSE® Sterile Solution (equivalent to 5 mg/mL dinoprost) 1 day prior to EAZI-BREED CIDR Cattle Insert removal, on Day 6 of the 7 day administration period.

• Observe animals for signs of estrus on Days 1 to 3 after removal of the EAZI-BREED CIDR Cattle Insert and inseminate animals about 12 hours after onset of estrus.

Insertion:

1. Avoid contact with skin by wearing protective gloves when handling inserts.

2. Only use the specially designed EAZI-BREED CIDR Cattle Insert Applicator for administration.

3. Restrain cattle appropriately (head catch, squeeze chute, gate, etc.) prior to administration.

4. Wash the EAZI-BREED CIDR Cattle Insert Applicator in a non-irritating antiseptic solution, and then lubricate the front portion of the EAZI-BREED CIDR Cattle Insert Applicator with a veterinary obstetrical lubricant.

5. Push the flexible tail end of the EAZI-BREED CIDR Cattle Insert into the EAZI-BREED CIDR Cattle Insert Applicator taking care to assure the tail is extending upward through the slot of the EAZI-BREED CIDR Cattle Insert Applicator and is pointed toward the handle.

6. Fold the wings of the EAZI-BREED CIDR Cattle Insert to make it longer and continue to advance the EAZI-BREED CIDR Cattle Insert into the applicator until it is fully seated. When fully seated only the tips of the wings should protrude (one half inch) from the end of the EAZI-BREED CIDR Cattle Insert Applicator (see Figure 1 below).

7. Lubricate the protruding tips of the wings of the EAZI-BREED CIDR Cattle Insert with veterinary obstetrical lubricant.

8. Lift the tail of the animal and clean the exterior of the vulva.

9. Open the lips of the vulva and gently place the loaded EAZI-BREED CIDR Cattle Insert Applicator through the vulva. The slot in the EAZI-BREED CIDR Cattle Insert Applicator should face upwards (see Figure 2 below).

10. Once the loaded EAZI-BREED CIDR Cattle Insert Applicator is past the vulva slope the EAZI-BREED CIDR Cattle Insert Applicator slightly upwards (35-45° angle) by lowering the handle, and then forward, without forcing, until the EAZI-BREED CIDR Cattle Insert Applicator is fully inserted or resistance is felt (see Figure 3 below).

11. Squeeze the finger grips within the handle of the EAZI-BREED CIDR Cattle Insert Applicator to deposit the EAZI-BREED CIDR Cattle Insert in the anterior vagina (see Figure 4 below) and then pull the EAZI-BREED CIDR Cattle Insert Applicator backwards to remove it from the vagina.

12. With the EAZI-BREED CIDR Cattle Insert correctly placed, with the wings open in the anterior portion of the vagina, the tail of the EAZI-BREED CIDR Cattle Insert should be visible, pointing downward from the vulva of the animal. Tails of EAZI-BREED CIDR Cattle Inserts that protrude more than 2.5 inches from the vulva may be clipped to minimize removal by other animals.

Removal:

1. Remove EAZI-BREED CIDR Cattle Inserts by pulling, gently but firmly, on the protruding polyester tail.

2. EAZI-BREED CIDR Cattle Inserts have been reported to reverse direction within the vagina; therefore, if the polyester tail of the insert is not visible on the day of removal, check the vagina to determine if an insert is present.

3. Used (removed) EAZI-BREED CIDR Cattle Inserts still contain some progesterone. Used EAZI-BREED CIDR Cattle Inserts must be stored in a sealable container until disposed. Sealed bag/container with used EAZI-BREED CIDR Cattle Inserts must be properly disposed in accordance with applicable local, state and Federal regulations.


OTHER INFORMATION:

Store at controlled room temperature 20° to 25°C (68° to 77°F) with excursions between 15° to 30°C (59° to 86°F).

To report suspected adverse events, for technical assistance or to obtain a copy of the SDS, contact Zoetis at 1-888-963-8471. For additional information about adverse drug experience reporting for animal drugs, contact FDA at 1-888-FDA-VETS or http://www.fda.gov/reportanimalae.

Restricted Drug (California) - use only as directed

Distributed by: Zoetis Inc., Kalamazoo, MI 49007

Inactive Ingredients: silicone rubber, nylon and polyester.

EAZI-BREED is a trademark and CIDR is a registered trademark of DEC International, NZ, Ltd.

39006604-04/19

CPN: 3690383.3

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