Dectomax Injectable Dewormer for Cattle and Swine

ZOETIS INC.
333 PORTAGE STREET, KALAMAZOO, MI, 49007
Telephone: 269-359-4414
Customer Service: 888-963-8471
Website: www.zoetis.com
THIS SERVICE AND DATA ARE PROVIDED "AS IS". DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. See the Terms of Use for further details.
DECTOMAX®

Zoetis

(doramectin injection)

Antiparasitic

1% injectable solution for cattle and swine

10 mg/mL

PRODUCT DESCRIPTION: Dectomax injectable solution is a ready-to-use, colorless to pale yellow, sterile solution containing 1% w/v doramectin (10 mg/mL). In cattle, Dectomax is formulated to deliver the recommended dosage (200 mcg/kg of body weight) when given by subcutaneous (SC) or intramuscular (IM) injection at the rate of 1 mL/110 lb of body weight. In swine, Dectomax is formulated to deliver the recommended dosage (300 mcg/kg of body weight) when given by IM injection at the rate of 1 mL/75 lb of body weight.

PRODUCT CHARACTERISTICS: Dectomax injectable solution is a highly active, broad-spectrum parasiticide for parenteral administration to cattle and swine. It contains doramectin, a novel fermentation-derived macrocyclic lactone. Doramectin is isolated from fermentations of selected strains derived from the soil organism Streptomyces avermitilis.

A primary mode of action of macrocyclic lactones is to modulate chloride ion channel activity in the nervous system of nematodes and arthropods. Macrocyclic lactones bind to receptors that increase membrane permeability to chloride ions. This inhibits the electrical activity of nerve cells in nematodes and muscle cells in arthropods and causes paralysis and death of the parasites. In mammals, the neuronal receptors to which macrocyclic lactones bind are localized within the central nervous system (CNS), a site reached by only negligible concentrations of doramectin.

One dose of Dectomax injectable solution effectively treats and controls a wide range of roundworm and arthropod parasites that impair the health and productivity of cattle and swine.

Studies have demonstrated the safety margin of Dectomax injection in cattle and swine. In USA trials, no toxic signs were seen in cattle given up to 25 times the recommended dose, or in swine given up to 10 times the recommended dose. Studies also demonstrated safety in neonatal calves and piglets treated with up to 3 times the recommended dose. In males (bulls and boars) and females (cows and sows during folliculogenesis, implantation, organogenesis, and through gestation), a dose 3 times the recommended dose had no effect on breeding performance.

PRODUCT INDICATIONS: Cattle: Dectomax injectable solution is indicated for the treatment and control of the following harmful species of gastrointestinal roundworms, lungworms, eyeworms, grubs (see PRECAUTIONS), sucking lice (see PRECAUTIONS), and mange mites. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

Gastrointestinal Roundworms (adults and fourth stage larvae)

Ostertagia ostertagi (including inhibited larvae)

O. lyrata

Haemonchus placei

Trichostrongylus axei

T. colubriformis

T. longispicularis1

Cooperia oncophora

C. pectinata1

C. punctata

C. surnabada (syn. mcmasteri)

Bunostomum phlebotomum1

Strongyloides papillosus1

Oesophagostomum radiatum

Trichuris spp.1

Lungworms (adults and fourth stage larvae)

Dictyocaulus viviparus

Eyeworms (adults)

Thelazia spp.

Grubs (parasitic stages)

Hypoderma bovis

H. lineatum

Sucking Lice

Haematopinus eurysternus

Linognathus vituli

Solenopotes capillatus

Mange Mites

Psoroptes bovis

Sarcoptes scabiei

1 adults

Dectomax injectable solution has been proved to effectively control infections and to protect cattle from reinfection with Cooperia oncophora and Haemonchus placei for 14 days, Ostertagia ostertagi for 21 days, and C. punctata, Oesophagostomum radiatum, and Dictyocaulus viviparus for 28 days after treatment.

Swine: Dectomax injectable solution is indicated for the treatment and control of the following species of gastrointestinal roundworms, lungworms, kidney worms, sucking lice (see PRECAUTIONS), and mange mites. Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

Gastrointestinal Roundworms (adults and fourth stage larvae)

Ascaris suum

Oesophagostomum dentatum

Oesophagostomum, quadrispinulatum1

Strongyloides ransomi1

Hyostrongylus rubidus1

Lungworms (adults)

Metastrongylus spp.

Kidney Worms (adults)

Stephanurus dentatus

Mange Mites (adults and immature stages)

Sarcoptes scabiei var. suis

Sucking Lice (adults and immature stages)

Haematopinus suis

1 adults

DOSAGE: Cattle: Administer Dectomax injectable solution at the recommended dosage of 200 mcg doramectin per kg (91 mcg/lb) of body weight. Each mL of DECTOMAX contains 10 mg of doramectin and 218 mg of ethyl oleate in a sesame oil vehicle, sufficient to treat 110 lb (50 kg) of body weight.

Body Weight (lb)

Dose (mL)

110

1

220

2

330

3

440

4

550

5

660

6

770

7

880

8

990

9

1,100

10

Swine: Administer Dectomax injectable solution at the recommended dosage of 300 mcg doramectin per kg (136 mcg/lb) of body weight. Each mL of DECTOMAX contains 10 mg of doramectin and 218 mg of ethyl oleate in a sesame oil vehicle, sufficient to treat 75 lb (34 kg) of body weight.

Body Weight (lb)

Dose (mL)

15

0.2

30

0.4

45

0.6

60

0.8

75

1.0

150

2.0

225

3.0

300

4.0

375

5.0

450

6.0

Do not underdose. Ensure each animal receives a complete dose based on a current body weight. Underdosing may result in ineffective treatment, and encourage the development of parasite resistance.

RECOMMENDED TREATMENT PROGRAM FOR SWINE: To effectively initiate control of mange and sucking lice in swine, it is important to treat all animals in the herd. After initial treatment, use Dectomax regularly as follows:

Breeding Animals:

Sows: Treat 7-14 days prior to farrowing to minimize exposure of piglets to mites and sucking lice.

Gilts: Treat 7-14 days prior to breeding. Treat 7-14 days prior to farrowing.

Boars: Treat a minimum of 2 times per year.

Feeder Pigs: Treat any new feeder pigs upon arrival at farm or before placement in clean quarters.

Weaners, Growers, Finishers: Weaners and grow-out/finisher pigs should be treated before placement in clean quarters.

For effective mange elimination, care must be taken to prevent reinfestation from exposure to untreated animals or contaminated facilities.

ADMINISTRATION: Dry, sterile equipment and aseptic procedures should be used when withdrawing and administering Dectomax. For multiple treatments either automatic injection equipment or an aspirating needle should be used.

Cattle: Administer Dectomax injectable solution by SC or IM route. Injections should be made using a 16 gauge needle for adult cattle or an 18 gauge needle for young animals. Needles 1/2-3/4” in length are suggested for SC administration. A 1-1/2” needle is suggested for IM administration. SC injections should be administered under the loose skin in front of or behind the shoulder. IM injections should be administered into the muscular region of the neck. Beef Quality Assurance guidelines recommend SC administration as the preferred route.


Swine: Administer Dectomax injectable solution by the IM route. Inject in the neck region using an 18 gauge x 1” needle for young animals; a 16 gauge x 1-1/2” needle for sows and boars. To accurately meter doses administered to piglets, use of a tuberculin syringe and 20 gauge x 1” needle is recommended.


WARNINGS: Not for human use. Keep out of reach of children. The safety data sheet (SDS) contains more detailed occupational safety information. To report adverse effects in users, to obtain more information, or to obtain an SDS, call 1-888-963-8471.

OTHER WARNINGS: Parasite resistance may develop to any dewormer, and has been reported for most classes of dewormers. Treatment with a dewormer used in conjunction with parasite management practices appropriate to the geographic area and the animal(s) to be treated may slow the development of parasite resistance. Fecal examinations or other diagnostic tests and parasite management history should be used to determine if the product is appropriate for the herd prior to the use of any dewormer. Following the use of any dewormer, effectiveness of treatment should be monitored (for example, with the use of a fecal egg count reduction test or another appropriate method). A decrease in a drug’s effectiveness over time as calculated by fecal egg count reduction tests may indicate the development of resistance to the dewormer administered. Your parasite management plan should be adjusted accordingly based on regular monitoring.


RESIDUE WARNINGS: Cattle: Do not slaughter for human consumption within 35 days of treatment. Not for use in female dairy cattle 20 months of age or older. A withdrawal period has not been established for this product in preruminating calves. Do not use in calves to be processed for veal. Swine: Do not slaughter for human consumption within 24 days of treatment.


PRECAUTIONS: Dectomax has been developed specifically for use in cattle and swine only. This product should not be used in other animal species as severe adverse reactions, including fatalities in dogs, may result.

For SC injection in cattle only. For IM injection in swine and cattle. This product is approved for the treatment and control of sucking lice. For treatment of biting lice in cattle, use of Dectomax Pour-On is recommended.

Dectomax is highly effective against all stages of cattle grubs. However, proper timing of treatment is important. For most effective results, cattle should be treated as soon as possible after the end of the heel fly (warble) season.

Destruction of Hypoderma larvae (cattle grubs) at the period when these grubs are in vital areas may cause undesirable host-parasite reactions including the possibility of fatalities. Killing H. lineatum when it is in the tissue surrounding the gullet may cause bloat; killing H. bovis when it is in the vertebral canal may cause staggering or paralysis. These reactions are not specific to treatment with Dectomax, but can occur with any successful treatment of grubs. Cattle should be treated either before or after these stages of grub development. Consult your veterinarian concerning the proper time for treatment.

Cattle treated with Dectomax after the end of the heel fly season may be re-treated with Dectomax during the winter for internal parasites, mange mites, or sucking lice, without danger of grub-related reactions. A planned parasite control program is recommended.

ENVIRONMENTAL SAFETY: Studies indicate that when doramectin comes in contact with the soil, it readily and tightly binds to the soil and becomes inactive over time. Free doramectin may adversely affect fish and certain aquatic organisms. Do not permit water runoff from feedlots to enter streams or ponds. Do not contaminate water by direct application or by the improper disposal of drug containers. Dispose of containers in an approved landfill or by incineration.

As with other avermectins, doramectin is excreted in the dung of treated animals and can inhibit the reproduction and growth of pest and beneficial insects that use dung as a source of food and for reproduction. The magnitude and duration of such effects are species and life-cycle specific. When used according to label directions, the product is not expected to have an adverse impact on populations of dung-dependent insects.

Store Below 30°C (86°F)

Use this product within 90 days of the first puncture and puncture a maximum of 25 times. If more than 25 punctures are anticipated, the use of automatic injection equipment or a repeater syringe is recommended. When using a draw-off spike or needle with bore diameter larger than 16 gauge, discard any product remaining in the vial immediately after use.

HOW SUPPLIED: Dectomax is available in 100-mL, 250-mL, and 500-mL multi-dose, rubber-capped glass vials.

Approved by FDA under NADA # 141-061

Consult your veterinarian for assistance in the diagnosis, treatment, and control of parasitism.

Not for human use.

Restricted Drug (CA) Use only as directed.

Distributed by:

Zoetis Inc., Kalamazoo, MI 49007

Product of China

Net Contents:



100 mL

Revised: February 2022

40031075

250 mL

Revised: September 2021

40031079

500 mL

Revised: September 2021

40031077

CPN: 3690009.10



COLORADO SERUM COMPANY4950 YORK STREET, P.O. BOX 16428, DENVER, CO, 80216-0428Telephone: 303-295-7527Order Desk: 800-525-2065Fax: 303-295-1923Website: www.colorado-serum.comEmail: colorado-serum@colorado-serum.comTHIS SERVICE AND DATA ARE PROVIDED "AS IS". DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. See the Terms of Use for further details.

TETANUS TOXOID-CONCENTRATED

Colorado Serum

Adjuvanted

GENERAL INFORMATION: This product has been shown to be effective for the vaccination of healthy horses, cattle, sheep, goats, and swine against tetanus. This product was licensed prior to the requirement to establish a minimum age for use. The duration of immunity is unknown. For more information regarding efficacy and safety data, see productdata.aphis.usda.gov.

Safety in pregnant animals is unknown.

Tetanus Toxoid is prepared by detoxifying tetanus toxin in such a manner as to allow the antigenic properties to remain intact. Product is purified, concentrated and adjuvanted to provide a low dose effective immunizing agent.

Each serial is tested for purity, safety, and potency in accordance with USDA requirements.

Tetanus is caused by a neurotoxin produced by growth of Clostridium tetani, an anaerobic (lives without air) micro-organism, in necrotic tissue. Affected animals become stiff, have difficulty swallowing, and have an increased pulse rate. Breathing is labored. Spasmodic contractions of the muscular system occur, such as contracting muscles of the jaw.

Spasmodic contractions of the muscular system occur, such as contracting muscles of the jaw. Thus, the term “lockjaw” is often used. Legs and tail are often stiff with abdominal muscles contracted. Tetanus stricken animals may be unusually sensitive to light and heat. Temperature of the animal generally remains normal, elevating only shortly before death.

Protective antibody levels usually occur about two weeks after the second injection of the primary immunization series. In contrast, administration of Tetanus Antitoxin is recommended for immediate, emergency, passive treatment of exposed animals with unknown vaccination history or with signs of tetanus infection.

DIRECTIONS: Do not vaccinate within 21 days before slaughter. Store at 2-8° C. Do not freeze. Do not mix with other products. Shake well before use. Use entire contents when first opened.

PRECAUTIONS: A transitory local reaction may occur at injection site. Anaphylactoid reaction may occur following administration of products of this nature. If noted, administer adrenalin or equivalent. In case of human exposure, consult a physician.

DOSAGE & ADMINISTRATION: For primary immunization, two doses should be administered subcutaneously or intramuscularly approximately 30 days apart. Use intramuscularly for horses as local reactions are more likely to occur if injected subcutaneously.

Horses: 1 ml IM

Cattle: 1 ml SC or IM

Sheep, Goats, Swine: 0.5 ml SC or IM

Historically, annual single dose revaccination has been recommended. Contact veterinarian for advice.

OTHER INFORMATION: Contains thimerosal and formalin as preservatives. Tetanus Toxoid Concentrate is available in single dose size packaged 10 vials to the carton, and in 10 dose vials.

THE PEAK OF QUALITY SINCE 1923

VLN: 188 / PCN: 8601.00

COLORADO SERUM COMPANY, 4950 York Street, Denver, Colorado 80216

303-295-752

www.colorado-serum.com

Contact us for information on other Colorado Serum Company products. Fine Veterinary Products since 1923.

FOR VETERINARY USE ONLY

Order #

10 - 1 ml vials

10 - 1 dose vials

11411

10 ml

10 doses

11415

CPN: 1101033.3