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CattleMaster GOLD FP 5 L5

CattleMaster GOLD FP 5 L5

Regular price $20.85 USD
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Modified-live and killed virus for the vaccination of healthy cattle of any age, including pregnant cows, as an aid in preventing abortion caused by IBR, persistently infected calves caused by BVD Types 1 & 2, and disease caused by IBR, BVD, Types 1 & 2, PI3, BRSV and the 5 most common strains of Lepto.

Dosage: 5 ml subcutaneously to healthy cattle, repeat in 3 weeks. As an aid in preventing IBR-induced abortion and BVD persistently infected calves, administer 5 ml dose at approx 5 weeks and 2 weeks prior to breeding. Calves vaccinated before 6 months of age should be revaccinated after 6 months. Revaccinate annually. 21 day slaughter withdrawal.

Risk-free Protection and Performance Guarantee

Manufacturer will guarantee 100 percent of calves born to be BVD PI-free provided that all cows and heifers have been vaccinated according to label directions at least 30 days prebreeding with Bovi-Shield GOLD FP, Bovi-Shield GOLD HB, PregGuard GOLD FP or CattleMaster GOLD FP vaccines. In addition, manufacturer will guarantee herds to be free of IBR abortions if cows and heifers were vaccinated according to label directions at least 30 days prebreeding with the family of FP vaccines.

Manufacturer and/or Label Information

Telephone: 269-359-4414
Customer Service: 888-963-8471
THIS SERVICE AND DATA ARE PROVIDED "AS IS". DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. See the Terms of Use for further details.
CattleMaster® GOLD FP® 5 L5


Bovine Rhinotracheitis-Virus Diarrhea-Parainfluenza3-Respiratory Syncytial Virus Vaccine

Modified Live and Killed Virus

Leptospira Canicola-Grippotyphosa-Hardjo-Icterohaemorrhagiae-Pomona Bacterin

PRODUCT DESCRIPTION: CattleMaster GOLD FP 5 L5 is for vaccination of healthy cattle, including pregnant cows, as an aid in preventing abortion caused by infectious bovine rhinotracheitis (IBR, bovine herpesvirus Type 1), persistently infected calves caused by bovine virus diarrhea (BVD) virus Types 1 and 2, respiratory disease caused by IBR, BVD (Types 1 and 2), parainfluenza3 (PI3), and bovine respiratory syncytial virus (BRSV) and leptospirosis caused by Leptospira canicola, L. grippotyphosa, L. hardjo, L. icterohaemorrhagiae, and L. pomona. CattleMaster GOLD FP 5 L5 is a freeze-dried preparation of chemically altered strains of IBR and PI3 viruses and modified live BRSV, plus a liquid, adjuvanted preparation of inactivated BVD virus (Types 1 and 2) and inactivated cultures of the 5 Leptospira serovars identified above. The liquid component is used to rehydrate the freeze-dried component. Viral antigens are propagated on an established cell line. This product is adjuvanted with a unique combination of adjuvants including Amphigen®. The BVD fraction of CattleMaster GOLD FP 5 L5 is further processed by a proprietary system to help assure consistency of the formulation.

DISEASE DESCRIPTION: IBR and BVD are commonly associated with reproductive and respiratory disease while BRSV and PI3 are predominantly associated with respiratory disease. IBR virus infection is characterized by high temperature, excessive nasal discharge, conjunctivitis and ocular discharge, inflamed nose (“red nose”), increased rate of respiration, coughing, loss of appetite, and depression. Cattle infected during pregnancy may abort. A characteristic of IBR virus is that it establishes a latent infection in sensory neurons, typically trigeminal ganglia or iliosacral dorsal root ganglia.1 From these sites of latency, it can be reactivated when an infected animal is stressed or injured. Subsequently, the virus is shed and transmitted by contact to other cattle.

BVD virus may be transmitted in nasal secretions, saliva, blood, feces, and/or urine, and by direct contact with contaminated objects; it invades through the nose and mouth and replicates systemically. Infection during pregnancy may result in abortion, fetal resorption, or congenital malformation of the fetus. Moreover, if susceptible cows are infected with noncytopathic BVD virus during the first trimester of pregnancy, their calves may be born persistently infected with the virus. Exposure of those calves to certain virulent BVD virus strains may precipitate BVD-mucosal disease. Clinical signs of BVD include loss of appetite, ulcerations in the mouth, profuse salivation, elevated temperature, diarrhea, dehydration, and lameness.

PI3 virus usually localizes in the upper respiratory tract, causing elevated temperature and moderate nasal and ocular discharge. Although clinical signs typically are mild, PI3 infection weakens respiratory tissues. Invasion and replication of other pathogens, particularly Pasteurella spp., is thereby facilitated and may result in pneumonia.

BRSV is the etiologic agent of a specific viral respiratory disease of cattle of all ages, including nursing calves. Infection is characterized by rapid breathing, coughing, loss of appetite, discharge from the nose and eyes, fever, and swelling around the throat and neck. In an acute outbreak, deaths may follow within 48 hours after onset of signs. Clinically, BRSV infection may be indistinguishable from other viral infections associated with the bovine respiratory disease complex. BRSV infection, like PI3, facilitates invasion and replication of other respiratory pathogens. Exacerbation of clinical signs has been documented when concurrent BRSV and BVD or IBR infection exists.

Leptospirosis may be caused by several serovars of Leptospira, of which L. canicola, L. grippotyphosa, L. hardjo, L. icterohaemorrhagiae, and L. pomona are the most common affecting cattle. Leptospira localize in the kidneys, are shed in the urine, and cause anemia, bloody urine, fever, loss of appetite, and prostration in calves. Signs are usually subclinical in adult cattle. Leptospira spp. are known zoonotic pathogens.

SAFETY AND EFFICACY: In safety studies of the fractions of CattleMaster GOLD FP 5 L5, no significant adverse reactions to vaccination were observed and vaccinated pregnant cattle delivered normal, healthy calves. Safety was demonstrated in pre-breeding and pregnant cows in all 3 trimesters. Transient local swelling was occasionally observed at the injection site.

The latency and subsequent excretion of the IBR virus fraction of CattleMaster GOLD FP 5 L5 was determined in a safety study in which cattle were vaccinated intramuscularly with the attenuated, temperature-sensitive IBR virus component and subsequently given corticosteroid to reactivate latent herpesvirus. Vaccination resulted in a characteristic serological response that remained unaltered even after corticosteroid treatment, indicating a lack of viral reactivation. Also, no BHV1 was recovered from mucosal swabs collected postvaccination or postcorticosteroid treatment, nor was it transmitted to nonvaccinated sentinel calves commingled with the vaccinates for the duration of the study. Further, no BHV1 DNA or latency-related RNA was detected in trigeminal or iliosacral spinal dorsal root ganglia collected after the administration of corticosteroid. Both nucleic acids were detected in a single cervical ganglion sample, suggesting a direct or proximate intraneural injection. BHV1 given by intramuscular (IM) injection could not be reactivated from trigeminal ganglia, the primary site of BHV1 latency, demonstrating a lack of efficient viral replication in those sensory neurons. Excluding possible injection into nervous tissue (from which reactivation was not observed), the IBR fraction of CattleMaster GOLD FP 5 L5 given by the IM route showed no propensity to establish latent herpesvirus infections.

Efficacy of each fraction of CattleMaster GOLD FP 5 L5 was demonstrated in challenge-of-immunity studies. Cattle vaccinated with any fraction of CattleMaster GOLD FP 5 L5, followed by challenge with a disease-causing strain of that fraction, had significantly fewer clinical signs than nonvaccinated control cattle.

Efficacy of the IBR and BVD Type 1 and 2 fractions of CattleMaster GOLD FP 5 L5 were additionally demonstrated in challenge-of-immunity, fetal protection studies. The effectiveness of the IBR fraction of CattleMaster GOLD FP 5 L5 in preventing IBR-induced abortion was demonstrated by vaccinating susceptible heifers approximately 5 and 2 weeks prior to breeding. The vaccinated heifers, along with a group of nonvaccinated controls, were challenged with virulent IBR virus (Cooper strain) at approximately 180 days postbreeding. Following challenge, > 90% of vaccinated cows gave birth to healthy calves whereas >90% of the nonvaccinated controls aborted.

A similar study design was used to demonstrate the effectiveness of CattleMaster GOLD FP 5 L5 in preventing persistently infected calves with both BVD Types 1 and 2. In these studies, cows were challenged at approximately 82 days postbreeding using virulent strains of BVD. In nonvaccinated controls, challenge with BVD Type 1 resulted in 100% fetal infection, and challenge with BVD Type 2 resulted in greater than 85% fetal infection. Conversely, 100% of calves born to cows vaccinated with CattleMaster GOLD FP 5 L5 were protected from persistent infection following challenge by both BVD Types 1 and 2.


1. General Directions: Vaccination of healthy cattle, including pregnant cows, is recommended. Aseptically rehydrate the freeze-dried vaccine with the liquid component provided, shake well, and administer 5 mL subcutaneously.

2. Primary Vaccination: Healthy cattle should receive an initial 2 doses 3 weeks apart. As an aid in preventing IBR-induced abortion and BVD persistently infected calves, administer a 5-mL dose at approximately 5 and 2 weeks prior to breeding. Calves vaccinated before the age of 6 months should be revaccinated after 6 months of age.

3. Revaccination: Annual revaccination with a single dose is recommended.

4. Good animal husbandry and herd health management practices should be employed.


1. Store at 2°-7°C. Prolonged exposure to higher temperatures and/or direct sunlight may adversely affect potency. Do not freeze.

2. Use entire contents when first opened.

3. Sterilized syringes and needles should be used to administer this vaccine. Do not sterilize with chemicals because traces of disinfectant may inactivate the vaccine.

4. Transient local reactions may be observed at the injection site.

5. Burn containers and all unused contents.

6. Do not vaccinate within 21 days before slaughter.

7. Contains gentamicin as preservative.

8. Routine handling of lactating dairy cattle, including administration of vaccines such as CattleMaster GOLD FP 5 L5, has been associated with transient reduction of milk production.

9. As with many vaccines, anaphylaxis may occur after use. Initial antidote of epinephrine is recommended and should be followed with appropriate supportive therapy.

10. This product has been shown to be efficacious in healthy animals. A protective immune response may not be elicited if animals are persistently infected with BVD virus or incubating an infectious disease, are malnourished or parasitized, are stressed due to shipment or environmental conditions, are otherwise immunocompromised, or the vaccine is not administered in accordance with label directions.


1. Jones C: Alphaherpesvirus latency: Its role in disease and survival of the virus in nature. Adv in Vir Res 51:81-133, 1999.

Technical inquiries should be directed to Zoetis Inc. Veterinary Services, (888) 963-8471 (USA), (800) 461-0917 (Canada).

For veterinary use only

U.S. Veterinary License No. 190

Zoetis Inc., Kalamazoo, MI 49007, USA


Presentation: 5 dose, 10 dose and 25 dose vials.

CPN: 3690219.4


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