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Merck Animal Health

ProSystem RCE-25 Dose

ProSystem RCE-25 Dose

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Size: 25 Dose

For use in healthy pregnant swine as an aid in the prevention of rotaviral diarrhea, enterotoxemia and colibacillosis in their
nursing piglets. Contains 2 major rotavirus serotypes, 4 major E. coli pilus antigens (K88, K99, F41 and 987P) and C. perfringens
type C toxoid

Manufacturer and/or Label Information

Intervet Inc.
Customer Service: 800-521-5767
Order Desk: 800-648-2118
Technical Service (Companion Animal): 800-224-5318
Technical Service (Livestock): 800-211-3573
Fax: 973-937-5557
THIS SERVICE AND DATA ARE PROVIDED "AS IS". DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. See the Terms of Use for further details.
ProSystem® RCE

Intervet/Merck Animal Health

Porcine Rotavirus Vaccine

Modified Live Virus

Clostridium Perfringens Type C-Escherichia Coli Bacterin-Toxoid

INDICATIONS: This product contains two major rotavirus serotypes, four major Escherichia coli pilus antigens (K88, K99, F41 and 987P) and Clostridium perfringens Type C (CpC) toxoid. When used in healthy pregnant swine, the rotavirus, E. coli K88, K99, F41 pilus antigens and CpC toxoid aid in prevention of rotaviral diarrhea, colibacillosis and enterotoxemia in their nursing piglets. Additionally, the E coli 987P antigen aids in the prevention of mortality and reduction of clinical disease caused by this serotype in nursing piglets.

SAFETY AND EFFICACY: Safety and efficacy of the Rotavirus vaccine and C. perfringens-E. coli bacterin-toxoid have been extensively evaluated in experimental tests and in field trials conducted by veterinarians. Both fractions have been demonstrated to be safe for pregnant swine and laboratory animals. Pregnant sows and gilts, when vaccinated intramuscularly with rotavirus, subsequently develop high persisting levels of rotavirus antibody in their milk, thereby aiding in the control of rotaviral diarrhea in their nursing pigs. Oral vaccination of sows and gilts with ProSystem® TGE/Rota (Porcine Rotavirus-Transmissible Gastroenteritis vaccine) also has been recommended as a means of reducing virus shedding and inducing high persisting levels of milk antibody. Either approach is satisfactory for prevention of rotaviral diarrhea in nursing pigs. Vaccination of pregnant swine with C. perfringens Type C toxoid and four major E. coli pilus antigens (K88, K99, F41 and 987P) also greatly reduced the incidence and severity of enterotoxemia and colibacillosis in their litters in experimental tests. Baby pigs are protected from rotaviral diarrhea, enterotoxemia and colibacillosis by receiving colostral and milk antibodies from vaccinated dams. Therefore, it is mandatory for both viral and bacterial passive immunity that sows and gilts are lactating and baby pigs are nursing.

DOSAGE AND DIRECTIONS: Shake bacterin-toxoid well. Restore accompanying vial of desiccated virus vaccine with 10-15 mL bacterin-toxoid and then transfer rehydrated vaccine back into plastic bacterin-toxoid bottle. Shake well, immediately inject a 2 mL dose intramuscularly into healthy pregnant swine at 5 weeks and again at 2 weeks before farrowing. In subsequent farrowings, inject one 2 mL dose 2 weeks before farrowing.

CAUTION: Store in the dark at 2° to 7°C (35° to 45°F). Do not freeze. Use immediately after reconstitution; do not save partial contents; burn both containers and all unused contents. Use only in healthy pregnant swine. Do not vaccinate within 21 days of slaughter. Conditions which interfere with lactation adversely affect immunity in baby pigs. If allergic reaction occurs, treat with epinephrine. Contains gentamicin, polymyxin B and thimerosal as preservatives.


Intervet Inc., Merck Animal Health, division of Intervet Inc., Omaha, NE 68103 USA

U.S. Veterinary License No. 165A


For patent information:


25 doses

50 mL



CPN: 1047368.3

COLORADO SERUM COMPANY4950 YORK STREET, P.O. BOX 16428, DENVER, CO, 80216-0428Telephone: 303-295-7527Order Desk: 800-525-2065Fax: 303-295-1923Website: www.colorado-serum.comEmail: colorado-serum@colorado-serum.comTHIS SERVICE AND DATA ARE PROVIDED "AS IS". DVMetrics assumes no liability, and each user assumes full risk, responsibility, and liability, related to its use of the DVMetrics service and data. See the Terms of Use for further details.


Colorado Serum


GENERAL INFORMATION: This product has been shown to be effective for the vaccination of healthy horses, cattle, sheep, goats, and swine against tetanus. This product was licensed prior to the requirement to establish a minimum age for use. The duration of immunity is unknown. For more information regarding efficacy and safety data, see

Safety in pregnant animals is unknown.

Tetanus Toxoid is prepared by detoxifying tetanus toxin in such a manner as to allow the antigenic properties to remain intact. Product is purified, concentrated and adjuvanted to provide a low dose effective immunizing agent.

Each serial is tested for purity, safety, and potency in accordance with USDA requirements.

Tetanus is caused by a neurotoxin produced by growth of Clostridium tetani, an anaerobic (lives without air) micro-organism, in necrotic tissue. Affected animals become stiff, have difficulty swallowing, and have an increased pulse rate. Breathing is labored. Spasmodic contractions of the muscular system occur, such as contracting muscles of the jaw.

Spasmodic contractions of the muscular system occur, such as contracting muscles of the jaw. Thus, the term “lockjaw” is often used. Legs and tail are often stiff with abdominal muscles contracted. Tetanus stricken animals may be unusually sensitive to light and heat. Temperature of the animal generally remains normal, elevating only shortly before death.

Protective antibody levels usually occur about two weeks after the second injection of the primary immunization series. In contrast, administration of Tetanus Antitoxin is recommended for immediate, emergency, passive treatment of exposed animals with unknown vaccination history or with signs of tetanus infection.

DIRECTIONS: Do not vaccinate within 21 days before slaughter. Store at 2-8° C. Do not freeze. Do not mix with other products. Shake well before use. Use entire contents when first opened.

PRECAUTIONS: A transitory local reaction may occur at injection site. Anaphylactoid reaction may occur following administration of products of this nature. If noted, administer adrenalin or equivalent. In case of human exposure, consult a physician.

DOSAGE & ADMINISTRATION: For primary immunization, two doses should be administered subcutaneously or intramuscularly approximately 30 days apart. Use intramuscularly for horses as local reactions are more likely to occur if injected subcutaneously.

Horses: 1 ml IM

Cattle: 1 ml SC or IM

Sheep, Goats, Swine: 0.5 ml SC or IM

Historically, annual single dose revaccination has been recommended. Contact veterinarian for advice.

OTHER INFORMATION: Contains thimerosal and formalin as preservatives. Tetanus Toxoid Concentrate is available in single dose size packaged 10 vials to the carton, and in 10 dose vials.


VLN: 188 / PCN: 8601.00

COLORADO SERUM COMPANY, 4950 York Street, Denver, Colorado 80216


Contact us for information on other Colorado Serum Company products. Fine Veterinary Products since 1923.




Order #

10 - 1 ml vials

10 - 1 dose vials


10 ml

10 doses


CPN: 1101033.3


Care information

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